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KMID : 0383819580050020083
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Tuberculosis and Respiratory Diseases
1958 Volume.5 No. 2 p.83 ~ p.87
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A STUDY ON PATHOGENESIS OF THE ANTITUBERCULOUS ORUG RESISTANT MYCOBACTERIUM TUBERCULOSA VOR BOVINIS
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이성관(李性寬)/Sung Kwan Lee
김경수(金炅守)/Kyung Koo Sim
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Abstract
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Though the appearance of the multiple antituberculous drugs marked a great epoch in
human combat wish tuberculosis, still another problem associated with development of
the mutant bacilli are we faced with.
The author examined the pathogenesis and changes in resistancy after animal passage,
by inoculatng INH-resistant and INH and SM resistant strains of the bovine type of
Mycobacterium tuberculosis to rabbits find guinea pigs.
1. The pathogenesis of the resistant strain, esoecially of the INH-resistant strain is
much attenuated as compared with that of the control strain.
2. The rate of finding bacteria in isolation culture is 100% in the control group, while
the rate is only is only 40% in the resistant groups.
3. The change in resistancy of the bacilli on isolating culture, is hardly observed in
the S-M resistant group, while marked loss of resistant was observed in the INH
resistant group.
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